During World War II, Louise Lomax joined the Army Nurse Corps (ANC) as a 2nd Lieutenant in March 1943 with the help of the National Association of Colored Graduate Nurses and trained as a psychiatric nurse at St. Elizabeths Hospital in Washington, D.C. By September 1943 she was stationed at Tuskegee Army Air Field in Alabama, home of the Tuskegee Airmen. Lomax remained at Tuskegee during the war, where she was eventually promoted to 1st Lieutenant.